Isabelle Migeotte

Occurrence of non-apical mitoses at the primitive streak, induced by relaxation of actomyosin and acceleration of the cell cycle, contributes to cell delamination during mouse gastrulation.

The paper shows that non-apical mitoses in the mouse gastrulation streak, driven by actomyosin relaxation and accelerated cell cycles, contribute to cell delamination, but not mesoderm identity.

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19

The paper identifies rare loss-of-function variants in type I IFN immunity genes associated with severe COVID-19, particularly in younger patients with recessive inheritance.

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality

This study examines how a major genetic risk factor for COVID-19 affects mortality and severity, finding stronger effects in younger adults.

Keratin dynamics govern the establishment of the maternal-fetal interface.

The paper investigates the role of keratin dynamics in post-implantation extra-embryonic membrane morphogenesis using live imaging and single-cell RNA sequencing in mouse embryos.

An asymmetry in the frequency and position of mitosis in the epiblast precedes gastrulation and suggests a role for mitotic rounding in cell delamination during primitive streak epithelial-mesenchymal transition.

The paper observes that non-apical mitosis in the posterior epiblast precedes gastrulation and is associated with cell delamination during epithelial-mesenchymal transition.

Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo

The paper shows that mesoderm cells in embryonic and extra-embryonic regions of the mouse embryo have distinct migration behaviors and cytoskeleton regulation.