Author

Peter P. De Cruz

The University of MelbourneORCID 0000-0002-3399-7236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alpha S. YapiD· 2 shared Erinna F. LeeiD· 2 shared John Martin MariadasoniD· 2 shared Juliani JulianiiD· 2 shared Kinga DuszyciD· 2 shared Sarah L. EllisiD· 2 shared Sharon H. TraniD· 2 shared Tiffany J. Harris· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Alpha S. YapORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Sufficient levels of BECLIN1 are required for intestinal epithelial cell homeostasis and protection against unwanted intestinal inflammation

Juliani Juliani, Sharon H. Tran, Tiffany J. Harris, Sarah L. Ellis, Aysha Al‐Ani, Komal M. Patel, Samuel N. Young, Marco Evangelista, David Baloyan, Camilla M. Reehorst, Rebecca Nightingale, Laura J. Jenkins, Peter P. De Cruz, Kinga Duszyc, Benjamin T. Kile, , Erinna F. Lee

This study shows that partial reduction of BECLIN1 in intestinal epithelial cells leads to intestinal defects and increased susceptibility to inflammation, suggesting its importance in maintaining gut health.

bioRxiv · Apr 29, 2025 · PreprintCell Biology

BECLIN-1 is Essential for the Maintenance of Gastrointestinal Epithelial Integrity by Regulating Endocytic Trafficking, F-actin Organization and Lysosomal Function

Juliani Juliani, Sharon H. Tran, Tiffany J. Harris, Peter P. De Cruz, Sarah L. Ellis, Paul A. Gleeson, John Martin Mariadason, Kinga Duszyc, Alpha S. Yap, Erinna F. Lee, Walter Douglas Fairlie

This study investigates the role of BECLIN-1 in maintaining gastrointestinal epithelial integrity by regulating endocytic trafficking, F-actin organization, and lysosomal function using organoids from BECLIN-1 knockout mice.

Autophagy Reports · Apr 3, 2025Peer-reviewedCell Biology