Alpha S. Yap

This study shows PIEZO1 supports apoptotic cell extrusion by maintaining mechanical homeostasis rather than through calcium signaling.

The paper introduces a method to analyze nematic order on tissue surfaces of arbitrary geometry, validated in vitro and in vivo, revealing physical insights through 3D reconstruction from 2D image stacks.

This study shows that partial reduction of BECLIN1 in intestinal epithelial cells leads to intestinal defects and increased susceptibility to inflammation, suggesting its importance in maintaining gut health.

This study investigates the role of BECLIN-1 in maintaining gastrointestinal epithelial integrity by regulating endocytic trafficking, F-actin organization, and lysosomal function using organoids from BECLIN-1 knockout mice.

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.

The paper introduces a transgenic Lifeact-EGFP quail line for live imaging of actin dynamics during avian embryogenesis and demonstrates its utility in studying cellular protrusions and supracellular actin structures.

This paper identifies anillin's role in RhoA contractile signaling by stabilizing active GTP-RhoA and promoting contractility through a non-classical scaffolding mechanism.