John Martin Mariadason

This study shows that blocking ICOS reduces immune suppression in breast tumors by altering Treg and CD8 T cell dynamics, enhancing anti-tumor immunity.

This study identifies Menin's MLL-independent role in promoting resistance to MAPK-targeted therapy in BRAF-mutant colorectal cancer.

This study identifies TAK1 as a cancer-intrinsic checkpoint that limits CD8+ T cell-mediated anti-cancer immunity by suppressing TNF and IFNγ-induced apoptosis, and shows that targeting TAK1 enhances anti-tumor responses.

This study shows that partial reduction of BECLIN1 in intestinal epithelial cells leads to intestinal defects and increased susceptibility to inflammation, suggesting its importance in maintaining gut health.

This study investigates the role of BECLIN-1 in maintaining gastrointestinal epithelial integrity by regulating endocytic trafficking, F-actin organization, and lysosomal function using organoids from BECLIN-1 knockout mice.