Ulrich Schlecht

The paper develops computational methods to accurately reconstruct adaptive immune receptor repertoires from partitioned B and T cell subsets, showing improved accuracy compared to pooling sub-repertoires.

HuBIE provides a large-scale immune-repertoire dataset from 1,941 participants, revealing ethnic and age-related differences in TCR and BCR diversity and linking immunological diversity to survival in elderly patients.

The paper develops a biosensor to study PDR regulation in yeast, identifying novel regulators and linking PDR to cell cycle control.

A yeast-based refactoring platform (HEx) with new inducible promoters, an engineered host strain, and homology-based assembly expressed 41 cryptic fungal gene clusters; 22 yielded non-native compounds.