Synthetic BiologyScience AdvancesPeer-reviewed
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HEx: a heterologous expression platform for the discovery of fungal natural products
Colin J. B. Harvey, Man‐Cheng Tang, Ulrich Schlecht…·Maureen E. Hillenmeyer
A yeast-based refactoring platform (HEx) with new inducible promoters, an engineered host strain, and homology-based assembly expressed 41 cryptic fungal gene clusters; 22 yielded non-native compounds.
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