Hosseinali Asgharian

The paper develops computational methods to accurately reconstruct adaptive immune receptor repertoires from partitioned B and T cell subsets, showing improved accuracy compared to pooling sub-repertoires.

This study benchmarks tumor-naive ctDNA detection and quantification methods using WGS and methylation data from cancer patients, identifying performance trade-offs and optimal integration strategies.

The paper introduces immunoPETE, a DNA-based platform for profiling B and T cell receptors, and demonstrates its performance in immune repertoire analysis and clinical applications.

The paper shows oxidative stress causes tyrosine tRNA fragmentation, leading to translational repression and growth suppression through depletion of the precursor tRNA and inhibition of transcript destabilization.

The paper identifies RBMS1 as a suppressor of colon cancer metastasis by stabilizing its mRNA targets, showing its clinical relevance in patient survival.

The paper estimates the effective population size and somatic mutation rate in asexual planarians using population genetic models and pedigree data.