Hubert Slawinski

The paper identifies immune signatures in TB contacts that predict protection or progression to active TB using single-cell RNA sequencing and correlates findings with non-human primate data.

This study identifies a hyper-inflammatory immune response in HIV-associated TB meningitis, marked by cytotoxic CD8 T cells, activated neutrophils, and type 1 interferon signaling.

This study identifies clonal persistence, tertiary lymphoid structures (TLS) engagement, and coordinated B-T cell immune surveillance as hallmarks of durable tumour control in a long-term survivor of metastatic ccRCC.

The paper investigates how HLA-DQβ157 polymorphism influences T cell receptor selection and links it to microbial antigens that mimic insulin, contributing to type 1 diabetes pathogenesis.

The paper shows that HLA class II haplotypes influence T1D risk by selecting for CD4+ T cell receptors with negatively charged CDR3β sequences that bind insulin, and demonstrates this in peripheral and islet T cells.