Author

Laurie G. Landry

University of Colorado AnschutzORCID 0000-0002-4064-9109Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

Maki NakayamaiD· 4 shared Agnieszka SzypowskaiD· 2 shared Amanda M. AndersoniD· 2 shared Arcadio Rubio GarcíaiD· 2 shared Athina PaterouiD· 2 shared Dominik Trzupek· 2 shared Hubert SlawinskiiD· 2 shared John A. ToddiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Maki NakayamaORCID

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4 papers

Recent·Most cited

Beta cell reactivity defines disease-relevant pancreatic CD8 T cells in type 1 diabetes

Amanda M. Anderson, Laurie G. Landry, Jessie M. Barra, Kristen L. Wells, Ali H. Shilleh, Roberto Castro-Gutiérrez, Andrew M. Ladd, Megan DeNicola, Jenny Aurielle B. Babon, Roberto Mallone, Sally C. Kent, Aaron W. Michels, Holger A. Russ, Maki Nakayama

This study identifies beta cell reactivity as a key feature distinguishing T1D-associated CD8 T cells from other pancreatic T cells.

bioRxiv · Jun 10, 2026 · PreprintImmunology

Tracking GAD-specific T-cell expansions in Type 1 diabetes by intradermal GAD-Alum challenge

Stephanie Jean Hanna, Emma Robinson, Terri C. Thayer, Maki Nakayama, Laurie G. Landry, Robert Andrews, Garry M. Dolton, Joanne E. Davies, Evangelia Williams, James Alexander Pearson, Andrew Kelvin Sewell, Parth Narendran, David Cameron Wraith, Alexandra Howell, Philippa Young, , Danijela Tatović

This paper uses intradermal GAD-Alum challenge and scRNA-seq to identify and profile GAD-reactive T cells in type 1 diabetes.

JCI Insight · May 22, 2026Peer-reviewedImmunology

Autoimmune interactions between the HLA-DQβ157 polymorphism, T cell receptors, and microbial mimics of insulin in type 1 diabetes

Arcadio Rubio García, Athina Paterou, Rebecca Powell Doherty, Laurie G. Landry, Mercede Lee, Amanda M. Anderson, Claire L. Scudder, Hubert Slawinski, Ricardo C. Ferreira, Dominik Trzupek, Agnieszka Szypowska, Luc Teyton, Nicola Ternette, Maki Nakayama, Linda S. Wicker, , Marcin Ł. Pękalski

The paper investigates how HLA-DQβ157 polymorphism influences T cell receptor selection and links it to microbial antigens that mimic insulin, contributing to type 1 diabetes pathogenesis.

medRxiv · May 11, 2022 · PreprintGenetic & Genomic Medicine

HLA class II mediates type 1 diabetes risk by anti-insulin repertoire selection

Arcadio Rubio García, Athina Paterou, Mercede Lee, Hubert Slawinski, Ricardo C. Ferreira, Laurie G. Landry, Dominik Trzupek, Luc Teyton, Agnieszka Szypowska, Linda S. Wicker, Maki Nakayama, John A. Todd, Marcin Ł. Pękalski

The paper shows that HLA class II haplotypes influence T1D risk by selecting for CD4+ T cell receptors with negatively charged CDR3β sequences that bind insulin, and demonstrates this in peripheral and islet T cells.

bioRxiv · Sep 6, 2021 · PreprintGenomics