Elma S. Frias

This study tracks the fate of monocyte-derived macrophages (MDMs) after traumatic brain injury (TBI) and finds they persist in the brain for up to 8 months, maintaining a distinct transcriptomic profile and phagocytic activity.

This study shows that inhibiting the integrated stress response (ISR) after concussive injury reverses cognitive deficits and aberrant cortical spine dynamics in mice.

This study shows that brain-engrafted macrophages protect against radiation-induced cognitive deficits and concussive injury by replacing microglia and altering their functional properties.

Inhibition of the integrated stress response restores neuronal and immune dysfunction and alleviates memory deficits in aged mice.