This study tracks the fate of monocyte-derived macrophages (MDMs) after traumatic brain injury (TBI) and finds they persist in the brain for up to 8 months, maintaining a distinct transcriptomic profile and phagocytic activity.

Nature Communications · Oct 7, 2025Peer-reviewedImmunology

Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition.

Elma S. Frias, Mahmood S. Hoseini, Karen Krukowski, Maria Serena Paladini, Katherine A. Grue, Gonzalo Ureta, Kira D. A. Rienecker, Peter Walter, Michael P. Stryker, Susanna Rosi

This study shows that inhibiting the integrated stress response (ISR) after concussive injury reverses cognitive deficits and aberrant cortical spine dynamics in mice.

Proceedings of the National Academy of Sciences · Oct 13, 2022Peer-reviewedNeuroscience

Open Data Commons for Preclinical Traumatic Brain Injury Research: Empowering Data Sharing and Big Data Analytics

Austin Chou, Abel Torres Espin, John Russell Huie, Karen Krukowski, Sangmi Lee, Amber Nolan, Caroline Guglielmetti, Bridget E. Hawkins, Myriam M. Chaumeil, Geoffrey T. Manley, Michael S. Beattie, Jacqueline C. Bresnahan, Maryann Elizabeth Martone, Jeffrey Sean Grethe, Susanna Rosi, Adam R. Ferguson

The paper introduces ODC-TBI, a platform for sharing preclinical TBI data, enabling big data analytics and machine learning to address heterogeneity in TBI research.

Neurotrauma Reports · Apr 5, 2022Peer-reviewedNeuroscience

Small molecule cognitive enhancer reverses age-related memory decline in mice.

Karen Krukowski, Amber Nolan, Elma S. Frias, Morgane Boone, Gonzalo Ureta, Katherine A. Grue, Maria Serena Paladini, Edward Elizarraras, Luz M. Delgado, Sebastián Bernales, Peter Walter, Susanna Rosi

Inhibition of the integrated stress response restores neuronal and immune dysfunction and alleviates memory deficits in aged mice.

eLife · Nov 30, 2020Peer-reviewedNeuroscience