Author

Honglei Weng

Heidelberg University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

Roman LiebeiD· 6 shared Steven DooleyiD· 6 shared Chenhao Tong· 4 shared Yujia LiiD· 4 shared Chen ShaoiD· 3 shared Chenjun HuangiD· 3 shared Hanno NießiD· 3 shared Hui LiuiD· 3 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersMolecular Biology

Roman LiebeORCID

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Author profile →

6 papers

Recent·Most cited

Transient suppression of the ECM1 gatekeeper is essential for HGF/c-MET-driven liver regeneration

Ye Yao, Yujia Li, Chenjun Huang, Jiayi Ma, Liang Xu, Stephanie D. Wolf, Julian Gilljam, Haifeng Zeng, Stefan Munker, Xioachun Cao-Ehlker, Ruochan Li, Bernhard Willibald Renz, Hanno Nieß, Seddik Hammad, Elisa Holstein, , Sai Wang

This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.

bioRxiv · Jun 10, 2026 · PreprintCell Biology

DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma

Tao Lin, Chenjun Huang, Chenhao Tong, Heng liu, Roman Liebe, Lungen Lu, Jun Li, Jonathan A. Lindquist, Matthias ebert, Peter Mertens, Steven Dooley, Honglei Weng

The paper identifies a YB-1-mA-DNMT regulatory axis that drives cisplatin resistance in iCCA by promoting ABCB1 expression through promoter demethylation.

bioRxiv · Jun 7, 2026 · PreprintMolecular Biology

TGF-β serves as a critical signaling determinant of liver progenitor cell fate and function

Chenhao Tong, Tao Lin, Han Wang, C de la Torre, Hui Liu, Chen Shao, Seddik Hammad, Roman Liebe, Matthias P Ebert, Huiguo Ding, Steven Dooley, Honglei Weng

This study identifies TGF-β as a key regulator of liver progenitor cell quiescence and activation, showing its dual role in inhibiting proliferation while being counteracted by HGF and EGF signals.

Zeitschrift für Gastroenterologie · Sep 1, 2025Peer-reviewedCell Biology

Regulation of essential hepatocyte functions and identity by super-enhancers in health and disease

Tao Lin, Chenjun Huang, Chenhao Tong, Wentao Xu, Han Wang, Shanshan Wu, Wenzhe Zhang, Yujia Li, Hui Liu, Chen Shao, Rui R Liu, Shanshan Wang, Stefan Munker, Hanno Nieß, Christoph Meyer, , Honglei Weng

This study identifies super-enhancers as critical regulators of liver function genes in hepatocytes and liver progenitor cells during health and acute liver failure.

bioRxiv · Jun 4, 2025 · PreprintMolecular Biology

FOXA2 is essential for maintaining the urea cycle in acute liver failure

Rilu Feng, Rui Liu, Chenhao Tong, Tao Lin, Xiaofeng Li, Hui Liu, Chen Shao, Kejia Kan, Carsten Sticht, Yujia Li, Sai Wang, Stefan Munker, Ulrich Wirth, Hanno Nieß, Roman Liebe, , Honglei Weng

This study identifies FOXA2's role in maintaining urea cycle function in acute liver failure by regulating CPS1 transcription and preventing hyperammonemia.

bioRxiv · Dec 11, 2023 · PreprintMolecular Biology

Rapid dexamethasone treatment inhibits LPS-induced cytokine storm in mice

Fen Zhang, Lanlan Xiao, Yujia Li, Rilu Feng, Menghao Zhou, Shima Tang, Roman Liebe, Matthias Ebert, Steven Dooley, Lanjuan Li, Honglei Weng

This study shows that rapid dexamethasone treatment inhibits LPS-induced cytokine storm in mice by blocking RNA Pol II activity in pre-loaded pro-inflammatory genes.

bioRxiv · Dec 7, 2023 · PreprintMolecular Biology