Author

Nicole Dam

Leiden University Medical CenterORCID 0000-0002-3457-0154Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Lukas J.A.C. HawinkelsiD· 2 shared Vera KempiD· 2 shared Bernhard SchmiereriD· 1 shared Bram W. van OsiD· 1 shared Casper H.J. van Eijck· 1 shared Casper W.F. van Eijck· 1 shared Gaby J. StrijkiD· 1 shared Gavriil Ioannidis· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Lukas J.A.C. HawinkelsORCID

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2 papers

Recent·Most cited

Cancer BiologyCancer Treatment and Research CommunicationsPeer-reviewedJan 1, 2026

Bulk RNA sequencing deconvolution of pancreatic ductal adenocarcinoma identifies cancer-associated fibroblast subsets associated with survival and tumor microenvironment composition

Nicole Dam, Mischa F.B. Steketee, Gaby J. Strijk…·Bram W. van Os

The paper uses bulk RNAseq deconvolution to identify CAF subtypes in early onset PDAC and links their abundance to survival and tumor microenvironment composition.

DOI 10.1016/j.ctarc.2026.101490

humanbulk RNA-seq

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Cancer BiologyMolecular Therapy OncologyPeer-reviewedOct 18, 2025

ZEB1, a novel regulator of Junctional Adhesion Molecule A, impacts sensitivity of pancreatic cancer-associated fibroblasts to oncolytic reovirus

Nicole Dam, Tom J. Harryvan, Hao Dang…·Vera Kemp

This study identifies ZEB1 as a regulator of JAM-A expression in pancreatic fibroblasts, showing that ZEB1 inhibition enhances reovirus sensitivity in these cells.

DOI 10.1016/j.omton.2025.201071

humangenetic perturbation / CRISPR

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