Author

Tom J. Harryvan

Leiden University Medical CenterORCID 0000-0002-0386-8302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Lukas J.A.C. HawinkelsiD· 2 shared Bernhard SchmiereriD· 1 shared Els M.E. VerdegaaliD· 1 shared Ezra J. van der WeliD· 1 shared Gavriil Ioannidis· 1 shared Hao Dang· 1 shared Imke StouteniD· 1 shared Kristiaan LenosiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Lukas J.A.C. HawinkelsORCID

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2 papers

Recent·Most cited

ZEB1, a novel regulator of Junctional Adhesion Molecule A, impacts sensitivity of pancreatic cancer-associated fibroblasts to oncolytic reovirus

Nicole Dam, Tom J. Harryvan, Hao Dang, Gavriil Ioannidis, Bernhard Schmierer, Lukas J.A.C. Hawinkels, Vera Kemp

This study identifies ZEB1 as a regulator of JAM-A expression in pancreatic fibroblasts, showing that ZEB1 inhibition enhances reovirus sensitivity in these cells.

Molecular Therapy Oncology · Oct 18, 2025Peer-reviewedCancer Biology

TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in CMS4 colorectal cancer subtype

Tom J. Harryvan, Subinuer Abudukelimu, Imke Stouten, Ezra J. van der Wel, Stefanus G. T. Janson, Kristiaan Lenos, Tamsin R.M. Lannagan, Mark White, Owen James Sansom, Els M.E. Verdegaal, Lukas J.A.C. Hawinkels

iScience · Oct 5, 2025Peer-reviewedCancer Biology