Nicolò Meneghetti

GABAergic Circuit Activation Induces a Therapeutically Responsive State for anti-PD-L1 Immunotherapy in Glioblastoma

This study shows that activating GABAergic circuits with baclofen enhances the effectiveness of anti-PD-L1 immunotherapy in glioblastoma, leading to tumor regression and prolonged survival in mice.

Can we trust subthalamic local field potentials? Geometric and dynamical constraints on the interpretation of extracellular recordings

This paper challenges the assumption that local field potentials (LFPs) universally reflect population activity by showing that their interpretability depends on neuronal morphology and synchronization state in the subthalamic nucleus.

In silico model of basal ganglia Deep Brain Stimulation in Parkinsons Disease captures range of effective parameters for pathological beta power suppression

The paper develops a computational model of basal ganglia DBS in Parkinson's disease to identify effective parameters for suppressing pathological beta oscillations.

Kernel-based LFP estimation in detailed large-scale spiking network model of mouse visual cortex

The paper introduces a kernel-based method to efficiently estimate LFPs in a mouse V1 model, showing external inputs dominate LFPs over local activity.

Altered cortical network in Parkinson's Disease: the central role of PV interneuron and synaptic remodelling

This study investigates cortical network disruptions in Parkinson's disease using a mouse model, finding PV interneuron dysfunction drives maladaptive plasticity and motor deficits.

Gamma oscillations in basal ganglia stem from the interplay between local inhibition and beta synchronization

This study identifies two distinct gamma rhythms in the basal ganglia using a spiking network model and shows their modulation in Parkinson's disease conditions.

A spiking LIF model captures the role of Somatostatin and Parvalbumin neurons in generating oscillations in V1

The paper uses a spiking LIF model to show that somatostatin and parvalbumin neurons generate beta and gamma oscillations in V1, respectively.

Thalamic inputs determine functionally distinct gamma bands in mouse primary visual cortex

The paper shows that two gamma bands in mouse V1 are modulated by distinct thalamic inputs and contrast ranges, with a model reproducing these dynamics.