Massimo Pasqualetti

Endogenous oxytocin reconfigures brainwide network dynamics toward salience-related states

This study shows that endogenous oxytocin alters brain network dynamics, increasing salience-related network states and decreasing sensory-dominated states in mice.

Pre-Existing Serotonergic Pathways Guide the Navigation of Developing Serotonergic Axons

This study shows that developing serotonergic axons follow pre-existing serotonergic pathways, supporting the epiphytic guidance hypothesis.

Live Holotomography of Growing Serotonergic Axons

This study uses high-resolution holotomography to visualize serotonergic axon growth dynamics in mouse embryos, revealing stochastic motion patterns and providing data for computational modeling.

GABAergic Circuit Activation Induces a Therapeutically Responsive State for anti-PD-L1 Immunotherapy in Glioblastoma

This study shows that activating GABAergic circuits with baclofen enhances the effectiveness of anti-PD-L1 immunotherapy in glioblastoma, leading to tumor regression and prolonged survival in mice.

Developmental excitation-inhibition imbalance permanently reprograms autism-relevant social brain circuits

This study shows that a transient developmental excitation-inhibition imbalance causes lasting social brain circuit dysfunction in mice, with behavioral and transcriptional consequences.

Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndrome

This study investigates developmental dysconnectivity in 22q11.2 deletion syndrome using a cross-species approach, finding age-specific fMRI connectivity changes with synaptic origins.

Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral and transcriptomic levels

This study shows that Ube3a gene overdosage causes sex-biased effects on brain connectivity, behavior, and gene expression in mice, linking it to autism-related phenotypes.

Cortical silencing results in paradoxical fMRI overconnectivity

The paper shows that silencing the prefrontal cortex paradoxically increases resting-state fMRI connectivity with its thalamo-cortical terminals.

A cross-species link between mTOR-related synaptic pathology and functional hyperconnectivityin autism

The paper links mTOR-related synaptic pathology to functional hyperconnectivity in autism using mouse models and human fMRI data.

Deletion of autism risk gene Shank3 disrupts prefrontal connectivity

This study shows that deleting the autism risk gene Shank3 in mice disrupts prefrontal connectivity and is linked to social communication deficits.

Serotonin Buffers Hippocampal Neuroplasticity And Emotional Behavior

This study investigates how serotonin deficiency affects hippocampal neuroplasticity and emotional behavior in mice, revealing a buffering role of serotonin in adaptive responses to environmental stress.

Brainwide Mapping Of Endogenous Serotonergic Transmission Via Chemogenetic-fMRI

This study uses chemogenetic-fMRI to identify brain regions activated by serotonergic stimulation, showing region-specific effects rather than global activity changes.

Homozygous loss of autism-risk gene CNTNAP2 results in reduced local and long-range prefrontal functional connectivity

This study shows that homozygous loss of CNTNAP2 in mice reduces prefrontal and midline brain functional connectivity, linking it to autism-related traits.