Anne‐Karine Bouzier‐Sore

This study shows that combining lactate with hypothermia improves neuroprotection in neonatal hypoxic-ischemic brain injury by enhancing lesion recovery and reducing neuroinflammation and apoptosis.

This study shows lactate reduces pro-inflammatory responses in microglia by decreasing inflammatory markers and increasing anti-inflammatory markers in vitro and in a neonatal rat hypoxia-ischemia model.

This study defines an optimal hypothermia protocol in a rat model of neonatal hypoxia-ischemia, finding that 2 hours of hypothermia provides the best neuroprotection.

The paper shows lactate-dependent glycolysis shifts produce D-serine, linking astrocyte metabolism to synaptic and cognitive functions through CB1 receptor activation.