Luc Pellerin

This study shows that combining lactate with hypothermia improves neuroprotection in neonatal hypoxic-ischemic brain injury by enhancing lesion recovery and reducing neuroinflammation and apoptosis.

This study defines an optimal hypothermia protocol in a rat model of neonatal hypoxia-ischemia, finding that 2 hours of hypothermia provides the best neuroprotection.

This study shows that MCT2 is essential for oligodendrocyte myelin maintenance and axonal support, and its loss leads to myelin and axonal damage, which can be mitigated by a ketogenic diet.

This study shows that astrocytic lactate supply via MCT4 and MCT2 is essential for maintaining wakefulness and sleep stability by supporting orexinergic neuron activity.

The paper shows lactate-dependent glycolysis shifts produce D-serine, linking astrocyte metabolism to synaptic and cognitive functions through CB1 receptor activation.

This paper develops a multimodal imaging approach using TROPUS to assess NAFLD in mice, enabling early detection of fat accumulation and liver damage through optical and acoustic contrasts.

This study shows reducing MCT1 worsens diabetic peripheral neuropathy in mice, suggesting caution in using MCT1 inhibitors for diabetic patients.