Stacey B. Whitbourne

Cross-ancestry and phenome-wide associations of cancer-specific polygenic risk scores

This study evaluates cancer-specific polygenic risk scores (PRS) across diverse ancestries and finds they predict corresponding cancers with varying effectiveness and limited pleiotropy.

Leveraging Large-Scale Biobanks for Therapeutic Target Discovery

This study uses large biobanks to identify gene-trait pairs with causal evidence, rediscover approved drug targets, and develop a predictive model for drug development.

Primary Care Providers' Perspectives on Receiving Tier 1 Genomic Results from a National Study- the Million Veteran Program Return of Actionable Results (MVP-ROAR) Study

The paper explores primary care providers' experiences with receiving genetic results from a national biobank study, highlighting challenges in integrating genetic information into routine care.

Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program

Population-stratified GWAS of 2,068 traits in 635,969 Million Veteran Program participants, 29% genetically non-European, yields 98,485 associations and 57,601 fine-mapped signals with largely shared cross-population architecture.

Introducing return of results in the Million Veteran Program: Design and pilot results of the MVP-ROAR Familial Hypercholesterolemia Study

The paper describes the design and pilot results of a study returning genetic results for familial hypercholesterolemia to MVP participants, showing a reduction in LDL-C after genetic counseling.

Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort

This study identifies correlates of risk for disinhibited behaviors in veterans using polygenic scores and electronic health records, finding strong associations with substance use disorders and related health outcomes.