K. Paige Harden

The paper examines how polygenic indices for educational attainment change across birth cohorts and regions in Germany, finding stronger associations in recent cohorts and the East but weaker effects for women.

The paper examines developmental correlates of epigenetic and polygenic indices of cognition and education from birth to young adulthood, finding Epigenetic-g is plastic in early childhood and captures distinct variation from polygenic indices.

This study identifies 1,294 genomic regions and 961 effector genes associated with externalizing disorders, revealing neural mechanisms and polygenic predictors of variance in these conditions.

This study identifies a genetic link between externalizing traits and suicide risk using genomic data and electronic health records from over 500,000 veterans.

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

The paper finds stronger polygenic associations with educational attainment in East Germans after reunification compared to West Germans.

This study identifies genetic variants associated with income and shows they correlate with health outcomes and educational attainment.

The paper describes the Gene-SOEP dataset, a longitudinal genetic study of 2,598 individuals in Germany, providing polygenic indices for research on genetic-environment interactions.

This study identifies correlates of risk for disinhibited behaviors in veterans using polygenic scores and electronic health records, finding strong associations with substance use disorders and related health outcomes.

This study examines the stability of DNA-methylation profiles of biological aging in children and adolescents over four years, finding moderate stability and less stability compared to adults.

This paper evaluates how down-sampling affects GWAS summary statistics and recommends reporting specific analyses to support their use.

This study uses Genomic Structural Equation Modeling to identify a common genetic factor underlying externalizing phenotypes and substance use disorders, finding that a single dimension of genetic risk best explains their relationships.

This study shows noncognitive skills become more predictive of academic achievement over time and their genetic contribution increases with age.

This study shows that epigenetic-BMI measured from children's saliva is a valid biomarker of BMI and reflects social inequalities in childhood and adolescence.

The paper tests if socioeconomic gradients observed in blood DNA methylation measures can be reproduced using buccal-cell DNA, finding smaller effect sizes and lower cross-tissue correlations.

The paper examines DNA-methylation profiles in children and adolescents, finding associations between social inequality and epigenetic markers of inflammation, cognitive functioning, and biological aging.

This study performs a multivariate GWAS on psychiatric disorders and symptoms to identify two genetic liabilities distinguishing common mood disturbances from serious mental illnesses.

This study identifies genetic variants associated with antisocial behavior through a genome-wide association meta-analysis, finding significant links to FOXP2 and correlations with multiple health and behavioral traits.

The paper constructs polygenic indexes for 47 phenotypes across 11 datasets and provides a tool to correct errors-in-variables bias when using PGIs as proxies for the additive SNP factor.

This paper conducts a multivariate GWAS of AUDIT items to correct biases and identify novel genetic associations between alcohol consumption, misuse, and health outcomes.

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

This study identifies 157 genome-wide significant loci associated with non-cognitive contributions to educational attainment, explaining 57% of genetic variance.

The paper uses multivariate genomic analysis of 1.5 million people to identify genetic loci related to addiction, antisocial behavior, and health, finding over 500 loci enriched for brain-expressed genes.

The paper evaluates the DunedinPoAm DNA methylation measure of aging pace in children and finds socioeconomic disadvantage is associated with faster aging, unlike other epigenetic clocks.

This study identifies genetic loci associated with macronutrient intake and links them to health outcomes using GWAS in over 235,000 individuals.

The paper uses polygenic scores to show that students from advantaged schools are more likely to take advanced math courses and persist in math, while disadvantaged schools track fewer high-potential students into advanced math.

The paper shows that environmental changes reveal new genetic influences on cortisol responses in children, challenging the idea that genetic variation only codes for fixed phenotypes.

The paper shows that two core brain networks supporting executive functions are established by middle childhood, with activity patterns similar to adults.

Structural equation modeling over GWAS summary statistics fits several traits jointly; across five psychiatric traits it surfaced 27 SNPs the univariate GWASs missed and sharpened polygenic scores.

The paper estimates genetic and environmental influences on testosterone, DHEA, and progesterone concentrations in human hair across 8-18 years in twins, identifying sex-specific heritability peaks.