Cancer BiologybioRxivPreprint
Time-Resolved Crystallography Reveals the Mechanisms of GTP hydrolysis for N-RAS and the Oncogenic Mutants G12C, G12V and Q61L
Guowu Lin, Paola Zinser Peniche, Xiaohong Zhou…·Guillermo A. Calero
This study uses time-resolved crystallography to capture GTP hydrolysis intermediates of N-RAS and oncogenic mutants, revealing shared and distinct reaction mechanisms.
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