Nicholas A. Crossland

This study uses deep learning to analyze spatial immune patterns in tuberculosis-infected mice, identifying distinct granuloma features associated with asymptomatic, acute, and chronic disease states.

This study shows that miR-223 improves cognitive function and reduces amyloid beta plaques in an Alzheimer's mouse model by enhancing microglial clearance.

The paper defines sub-phenotypes of pneumonia using histopathological features from human lung samples and validates them in mouse models.

This study identifies immune signatures associated with SARS-CoV-2 infection resolution in human lung tissues using a humanized mouse model.

The paper develops a mouse model that exhibits severe SARS-CoV-2 infection and post-acute systemic diseases, revealing molecular mechanisms of PASC.

This paper describes a mouse model of post-primary pulmonary tuberculosis that simulates hematogenous spread to the lungs and allows study of lung-specific TB mechanisms.

This paper introduces a protocol for 3D multiplexed immunohistochemistry using Opal-TSA conjugated fluorescent dyes to enhance imaging of pulmonary TB lesions in mouse tissues.

This study shows that pre-existing H1N1 immunity protects ferrets from severe disease caused by bovine H5N1 influenza virus.

The paper investigates the effects of liver-specific Mettl14 deletion, finding it causes nuclear heterotypia and disrupts RNA export machinery.

This study identifies Myc dysregulation in macrophages as a driver of TB susceptibility by linking lipid peroxidation and IFN-I pathway hyperactivity.