Leaked genomic and mitochondrial DNA contribute to the host response to noroviruses in a STING-dependent manner
Aminu S. Jahun, Frédéric Sorgeloos, Yasmin Chaudhry, Sabastine Eugene Arthur, Myra D.T. Hosmillo, Iliana Georgana, Rhys Izuagbe, Ian Goodfellow
This study shows that the cGAS-STING pathway restricts noroviruses by detecting leaked genomic and mitochondrial DNA, leading to IFN responses.
Cell Reports · Mar 1, 2023Peer-reviewedMolecular Biology