Iliana Georgana

COVID-19 vaccination induces cross-neutralisation of sarbecoviruses related to SARS-CoV-2

This study assesses cross-neutralisation of sarbecoviruses by COVID-19 vaccines in older adults, finding reduced neutralisation of Omicron variants and some animal sarbecoviruses but enhanced neutralisation of specific bat and pangolin coronaviruses.

Encephalomyocarditis virus protein 2B* antagonises innate immune signalling by interacting with 14-3-3 protein family members

This paper identifies 2B* as an EMCV protein that antagonizes innate immune signaling by interacting with 14-3-3 proteins, specifically through the RRNSS sequence.

Leaked genomic and mitochondrial DNA contribute to the host response to noroviruses in a STING-dependent manner

This study shows that the cGAS-STING pathway restricts noroviruses by detecting leaked genomic and mitochondrial DNA, leading to IFN responses.

Patterns of within-host genetic diversity in SARS-CoV-2

This study analyzes within-host genetic diversity in 1,181 SARS-CoV-2 samples, finding high mutation rates, strand asymmetries, and purifying selection, with implications for transmission chain reconstruction.

Cullin-5 adaptor SPSB1 controls NF-κB activation downstream of multiple signalling pathways

This study identifies SPSB1 as a negative regulator of NF-κB activation, showing its specificity for NF-κB and its role in inflammation and innate immunity.