The paper develops and validates a polygenic score for osteoporosis in Japanese individuals using heel quantitative ultrasound data, showing genetic risk stratification.

Journal of Human Genetics · Sep 9, 2026Peer-reviewedGenetic & Genomic Medicine

Polygenic Risk Score Stratification Guides Prioritization of Modifiable Risk Factors for Stroke Prevention

Yoichi Sutoh, Tsuyoshi Hachiya, Yayoi Otsuka‐Yamasaki, Motoki Nakao, Shinichi Omama, Yorihiko Koeda, Hiroshi Akasaka, Yuka Kotozaki, Shohei Komaki, Shiori Minabe, Hideki Ohmomo, Naoyuki Nishiya, Makoto Sasaki, Kozo Tanno, Atsushi Shimizu

This study shows that modifiable risk factors have varying impacts on stroke risk depending on genetic predisposition, with higher genetic risk amplifying the effect of these factors.

medRxiv · Jul 1, 2026 · PreprintGenetic & Genomic Medicine

Real-world data from the Japanese National Health Insurance System enable fine phenotyping in a 14K-scale population-based study

Yayoi Otsuka‐Yamasaki, Naoyuki Nishiya, Yoichi Sutoh, Reiko Aoyama, Kozo Tanno, Motoki Nakao, Shohei Komaki, Shiori Minabe, Hideki Ohmomo, Koichi Asahi, Yasushi Ishigaki, Makoto Sasaki, Atsushi Shimizu

The paper uses Japanese health insurance claims data to improve disease prevalence estimation and GWAS results for Alzheimer's and Parkinson's diseases.

medRxiv · Oct 6, 2025 · PreprintGenetic & Genomic Medicine

Proto-MHC signatures in the lamprey genome

Yoichi Sutoh, Kanako Ono, Shiori Minabe, Samadhi Senanayake, Hideki Ohmomo, Tsuyoshi Hachiya, Atsushi Shimizu, Masayuki Hirano

This study identifies proto-MHC-like regions in the sea lamprey genome, showing synteny with human MHC and amphioxus proto-MHC, but lacking core MHC genes.

bioRxiv · Mar 16, 2025 · PreprintEvolutionary Biology