Atsushi Shimizu

This study shows that modifiable risk factors have varying impacts on stroke risk depending on genetic predisposition, with higher genetic risk amplifying the effect of these factors.

The paper uses Japanese health insurance claims data to improve disease prevalence estimation and GWAS results for Alzheimer's and Parkinson's diseases.

This study identifies proto-MHC-like regions in the sea lamprey genome, showing synteny with human MHC and amphioxus proto-MHC, but lacking core MHC genes.

The paper identifies a mtDNA polymorphism in MOTS-c associated with increased T2D risk in males, interacting with physical activity.

A large-scale GWAS in 212,453 Japanese individuals identified 45 novel susceptibility loci for 22 diseases, highlighting the importance of non-European population studies.

The paper constructs a population-level allele frequency panel of 3,552 Japanese individuals using a standardized pipeline and makes it publicly available.

This study identifies 14 nephrolithiasis susceptibility loci in the Japanese population, including 9 novel loci, and links them to metabolic and crystallization pathways.