This study shows that modifiable risk factors have varying impacts on stroke risk depending on genetic predisposition, with higher genetic risk amplifying the effect of these factors.

medRxiv · Jul 1, 2026 · PreprintGenetic & Genomic Medicine

Genome-wide Association Study of Social Isolation in 63 497 Japanese Individuals from the General Population

Hisashi Ohseto, Kosuke Inoue, Ippei Takahashi, Taku Obara, Akira Narita, Mami Ishikuro, Masatsugu Orui, Keiko Murakami, Aoi Noda, Genki Shinoda, Masato Takase, Nakaya Naoki, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, , Shinichi Kuriyama

This study identifies genetic loci associated with social isolation in a Japanese population using GWAS, finding associations with ACADSB, HMX3, LINC02315, and LRFN5.

Translational Psychiatry · Feb 17, 2026Peer-reviewedGenetic & Genomic Medicine

Real-world data from the Japanese National Health Insurance System enable fine phenotyping in a 14K-scale population-based study

Yayoi Otsuka‐Yamasaki, Naoyuki Nishiya, Yoichi Sutoh, Reiko Aoyama, Kozo Tanno, Motoki Nakao, Shohei Komaki, Shiori Minabe, Hideki Ohmomo, Koichi Asahi, Yasushi Ishigaki, Makoto Sasaki, Atsushi Shimizu

The paper uses Japanese health insurance claims data to improve disease prevalence estimation and GWAS results for Alzheimer's and Parkinson's diseases.

medRxiv · Oct 6, 2025 · PreprintGenetic & Genomic Medicine

Genome-wide association meta-analysis identifies novel GP2 gene risk variants for pancreatic cancer in the Japanese population

Yingsong Lin, Masahiro Nakatochi, Yasuyuki Hosono, Hidemi M. Ito, Yoichiro Kamatani, Akihito Inoko, Hiromi Sakamoto, Fumie Kinoshita, Yumiko Kobayashi, Hiroshi Ishii, Masato Ozaka, Takashi Sasaki, Masato Matsuyama, Naoki Sasahira, Manabu Morimoto, , Keitaro Matsuo

Nature Communications · Jun 24, 2020Peer-reviewedGenetics

Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases

Kazuyoshi Ishigaki, Masato Akiyama, Masahiro Kanai, Atsushi Takahashi, Eiryo Kawakami, Hiroki Sugishita, Saori Sakaue, Nana Matoba, Siew‐Kee Low, Yukinori Okada, Chikashi C. Terao, Tiffany Amariuta, Steven Gazal, Yuta Kochi, Momoko Horikoshi, , Yoichiro Kamatani

A large-scale GWAS in 212,453 Japanese individuals identified 45 novel susceptibility loci for 22 diseases, highlighting the importance of non-European population studies.

Nature Genetics · Jun 8, 2020Peer-reviewedGenetics