Tsuyoshi Hachiya

Osteoporosis Genetic Risk Prediction Using Bone Mineral Density Polygenic Scores in Japanese: TMM CommCohort Study

The paper develops and validates a polygenic score for osteoporosis in Japanese individuals using heel quantitative ultrasound data, showing genetic risk stratification.

Polygenic Risk Score Stratification Guides Prioritization of Modifiable Risk Factors for Stroke Prevention

This study shows that modifiable risk factors have varying impacts on stroke risk depending on genetic predisposition, with higher genetic risk amplifying the effect of these factors.

Recurrent stroke prediction by applying a stroke polygenic risk score in the Japanese population

This study develops a polygenic risk score (metaGRS) for predicting recurrent stroke in the Japanese population using data from the BioBank Japan cohort, finding it associates with increased recurrence risk, particularly in individuals without hypertension.

Proto-MHC signatures in the lamprey genome

This study identifies proto-MHC-like regions in the sea lamprey genome, showing synteny with human MHC and amphioxus proto-MHC, but lacking core MHC genes.