Author

Philipp Rühl

Jena University HospitalORCID 0000-0002-3554-3107Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:electrophysiology· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

Anagha Gopalakrishnan NairiD· 3 shared Stefan H. HeinemanniD· 3 shared Hyeonsoo BaeiD· 1 shared Jürgen PoppiD· 1 shared Konrad FrahnertiD· 1 shared Lina Seeber· 1 shared Marko RodewaldiD· 1 shared Michael P. SchmittiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersPhysiology

Anagha Gopalakrishnan NairORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Sub-Millivolt Voltage Imaging Reveals Gap Junction-Mediated Bioelectric Contact Inhibition

Philipp Rühl, Rama Ashraf Hussein, Stefanie Reuter, Konrad Frahnert, Anagha Gopalakrishnan Nair, Ralf Mrowka, Roland Schönherr, Stefan H. Heinemann

The paper introduces a new voltage indicator to image sub-millivolt membrane potentials and discovers bioelectric contact inhibition mediated by gap junctions.

Nature Communications · Aug 15, 2026Peer-reviewedBiophysics

Structural compatibility enables functional co-assembly of Kir2.1 channels and the voltage-sensing domain of voltage-sensitive phosphatases

Anagha Gopalakrishnan Nair, Philipp Rühl, Lina Seeber, Toshinori Hoshi, Roland Schoenherr, Stefan H. Heinemann

This study shows that Kir2.1 channels and voltage-sensing domains can co-assemble into functional KV-like complexes, altering voltage-dependent fluorescence responses.

bioRxiv · Aug 7, 2026 · PreprintPhysiology

Absolute Membrane Potential Recording with ASAP-Type Genetically Encoded Voltage Indicators Using Fluorescence Lifetime Imaging

Anagha Gopalakrishnan Nair, Marko Rodewald, Hyeonsoo Bae, Philipp Rühl, Jürgen Popp, Michael P. Schmitt, Tobias Meyer‐Zedler, Stefan H. Heinemann

This paper evaluates genetically encoded voltage indicators using FLIM to measure absolute membrane potential, finding that rEstus-NI provides the highest sensitivity and accuracy.

ACS Chemical Neuroscience · Nov 22, 2025Peer-reviewedPhysiology