Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience.
Marios C. Panayi, Thomas Boerner, Thomas Jahans-Price, Anna Huber, Rolf Sprengel, Gary Gilmour, David J. Sanderson, Paul J. Harrison, Mark E. Walton, David M. Bannerman
This study shows that GluA1 dysfunction leads to impaired short-term habituation, resulting in a hyper-dopaminergic phenotype in the nucleus accumbens, which may contribute to aberrant salience in schizophrenia.
Molecular Psychiatry · Dec 2, 2022Peer-reviewedNeuroscience