Daniel Tödt

Impact of hepatitis E virus host- and virus-derived insertions on the antiviral response in primary human hepatocytes

This study examines how different HEV HVR insertion variants affect host transcriptomic responses in PHHs, finding that HVR duplication variants elicit weaker host responses and reduced ISG induction.

A sequence variation between two orthologues alters functional expression of the potassium channel Kesv of Ectocarpus siliculosus virus

This study compares the functional expression of two potassium channels, Kesv 1 and Kesv 2, identifying sequence differences that affect ion conductance and drug sensitivity.

Yellow fever vaccine propagation in primary human hepatocytes triggers antiviral and cytolytic responses

This study compares antiviral and cytolytic responses in primary human hepatocytes to YFV vaccine and virulent strains, finding similar propagation kinetics but distinct transcriptional responses.

Glycyrrhizin effectively neutralizes SARS-CoV-2 in vitro by inhibiting the viral main protease

This study shows glycyrrhizin inhibits SARS-CoV-2 main protease and neutralizes the virus in vitro, suggesting it as a potential antiviral treatment for COVID-19.