Yannick Brüggemann

Oncomimetic β-catenin activity onset, duration and region defines aberrant intestinal development

This study uses a chemical-optogenetic approach to control β-catenin activity in mouse small intestinal organoids, revealing persistent aberrant phenotypes and altered differentiation during homeostasis.

Yellow fever vaccine propagation in primary human hepatocytes triggers antiviral and cytolytic responses

This study compares antiviral and cytolytic responses in primary human hepatocytes to YFV vaccine and virulent strains, finding similar propagation kinetics but distinct transcriptional responses.

Interdependence of EGFR with PTPs on juxtaposed membranes generates a growth factor sensing and responding network

The paper identifies how EGFR interacts with PTPs on juxtaposed membranes to create a network that senses and responds to growth factor signals.