Promoter-centric gene regulation in drug-resistant cancer
Vasumathi Kameswaran, Sayantanee Paul, Daniel X. Le, Jonathan Hoover, Lu Zhao, Alissa D. Guarnaccia, Thijs J. Hagenbeek, Jessica M. Lund, Ana Xavier‐Magalhães, Minyi Shi, Julia Lau, Marco Claudio De Simone, Yuxin Liang, Anwesha Dey, Zora D. Modrusan, Bence Dániel
This study shows that mesothelioma cells develop drug resistance by reverting to a promoter-centric gene regulation mechanism when treated with a TEAD inhibitor.
bioRxiv · Feb 20, 2025 · PreprintCancer Biology