Author

Alissa D. Guarnaccia

GenentechORCID 0000-0003-4195-2158Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anwesha DeyiD· 2 shared Bence DánieliD· 2 shared Sayantanee PauliD· 2 shared Thijs J. HagenbeekiD· 2 shared Vasumathi KameswaraniD· 2 shared Ana Xavier‐MagalhãesiD· 1 shared Benjamin J. TomblingiD· 1 shared Carsten PeukertiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Anwesha DeyORCID

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2 papers

Recent·Most cited

Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewedJul 3, 2025

TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway

Alissa D. Guarnaccia, Thijs J. Hagenbeek, Wendy Lee…·Jennie Rebecca Lill

The paper identifies small molecules that induce a cofactor switch in TEAD proteins from YAP to VGLL4, repressing pro-growth gene networks and showing anti-proliferative effects.

16 citationstop 2%

humanproteomics

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Cancer BiologybioRxivPreprintFeb 20, 2025

Promoter-centric gene regulation in drug-resistant cancer

Vasumathi Kameswaran, Sayantanee Paul, Daniel X. Le…·Bence Dániel

This study shows that mesothelioma cells develop drug resistance by reverting to a promoter-centric gene regulation mechanism when treated with a TEAD inhibitor.

2 citations

humanChIP-seq

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