Extracellular vesicles from a model of melanoma cancer-associated fibroblasts induce changes in brain microvascular cells consistent with pre-metastatic niche priming.
Mikayla Shelton, Chinedu Anthony Anene, Jérémie Nsengimana, Mahmoud K. Eldahshoury, Jacob G. Gillet‐Woodley, Ben Keane, Wayne Roberts, Julia Newton‐Bishop, James R. Boyne
This study shows that melanoma cancer-associated fibroblast-derived extracellular vesicles alter the tumor microenvironment and pre-metastatic niche, promoting melanoma metastasis.
Journal of Extracellular Biology · Oct 30, 2025Peer-reviewedCancer Biology