Julia Newton‐Bishop

Large distant deletion disrupts CDKN2A enhancer and predisposes to melanoma

The paper identifies a large distant deletion in DMRTA1 upstream of CDKN2A that predisposes to melanoma by disrupting regulatory sequences and reducing p16 expression.

Functional characterization of the 9q34.13 locus identifies RAPGEF1 as modulating risk for melanoma and nevi via RAS activation

This study identifies RAPGEF1 as a gene modulating melanoma and nevi risk through RAS activation, using fine-mapping, expression data, and functional assays.

Extracellular vesicles from a model of melanoma cancer-associated fibroblasts induce changes in brain microvascular cells consistent with pre-metastatic niche priming.

This study shows that melanoma cancer-associated fibroblast-derived extracellular vesicles alter the tumor microenvironment and pre-metastatic niche, promoting melanoma metastasis.

Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis

This study shows glucocorticoids enhance anti-tumor immunity by inhibiting the GARP/TGF-β axis in melanoma, improving prognosis and response to immunotherapy.

The microenvironment of ulcerated acral melanoma is characterised by an inflammatory milieu and an enhanced humoral immune response

This study identifies immunological differences in ulcerated acral melanoma, showing increased humoral immunity and inflammation markers, and proposes potential therapeutic targets.

Population-based analysis of POT1 variants in a cutaneous melanoma case-control cohort

The paper analyzes POT1 variants in a melanoma case-control cohort, finding that pathogenic variants are a minor contributor to melanoma risk but should be screened in high-risk individuals.

Tumour gene expression signature in primary melanoma predicts long-term outcomes: A prospective multicentre study

This paper develops a gene expression signature, Cam_121, to predict long-term outcomes in primary melanoma patients, showing improved accuracy compared to clinical and existing prognostic models.