LINE-associated cryptic splicing induces dsRNA-mediated interferon response and tumor immunity
Rong Zheng, Mikayla Dunlap, Jingyi Lyu, Carlos Gonzalez‐Figueroa, Georg O.M. Bobkov, Samuel E. Harvey, Tracey W. Chan, Giovanni Quinones-Valdez, Mudra Choudhury, Amy Vuong, Ryan A. Flynn, Howard Y. Chang, Xinshu Grace Xiao, Chonghui Cheng
This study identifies hnRNPM as a suppressor of cryptic splicing and shows its role in preventing dsRNA-mediated interferon responses and tumor immunity.
bioRxiv · Feb 23, 2023 · PreprintGenomics