Astrocyte cell-surface proteomics identified CD44 as an OPN/SPP1 receptor regulating lipid metabolism and glial crosstalk in Alzheimer s disease
Omar Peña-Ramos, Manasee Gedam, Xue Zhang, Shuo Wang, Chuangye Qi, Tzu-Hsuan Huang, Chetan Singh Rajpurohit, Mikayla Dunlap, Yu Deng, Nicole Auld, Sung Yun Jung, Hongjie Li, Jun Li, Liqun Luo, Junmin Peng, , Hui Zheng
The paper identifies CD44 as an OPN receptor in astrocytes that regulates lipid metabolism and glial communication in Alzheimer's disease.
bioRxiv · Dec 9, 2025 · PreprintNeuroscience