NeurosciencebioRxivPreprint
Arrestin-3 promotes locomotor sensitization to psychostimulants via JNK signaling in nucleus accumbens
Mohamed Rafiuddin Ahmed, Jeffery L. Dunning, Chen Zheng…·Eugenia V. Gurevich
DOI 10.64898/2026.04.28.719936
Author
Chen Zheng
Vanderbilt UniversityORCID 0000-0002-3610-5715Unclaimed ORCID profile · follow to get notified of new preprints
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Biology Disciplines
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2023-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 21 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- Cell BiologybioRxivPreprint
Arrestin-3 scaffolds multiple MAP3Ks driving stress-induced JNK3 activation and cell death.
Chen Zheng, Mohamed Rafiuddin Ahmed, Richard C. Sando…·Eugenia V. Gurevich
This study identifies arrestin-3 as a scaffold for multiple MAP3Ks, with ZAK being the main mediator of JNK3 activation and chemotherapy-induced cell death in HEK293 cells.
DOI 10.64898/2026.03.09.710604 - Molecular BiologybioRxivPreprint
Cytoplasmic tail composition modulates the G protein and arrestin-3 signaling bias of the adhesion GPCR LPHN2
Krassimira A. Garbett, Chen Zheng, Julia Drube…·Richard C. Sando
This study shows that the C-terminal tail of LPHN2 modulates G protein and arrestin-3 signaling bias through alternative splicing and GRK interactions.
2 citations - Cell BiologyCommunications ChemistryPeer-reviewed
A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor
Han Kurt, Ali Akyol, Çağdaş Devrim Son…·Özge Şensoy
A small molecule stabilizes the pre-activated state of arrestin-3, enhancing its binding to phosphorylation-deficient β2-adrenergic receptors.
4 citations - NeurosciencebioRxivPreprint
Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral and signaling plasticity in vivo.
Mohamed Rafiuddin Ahmed, Chen Zheng, Jeffery L. Dunning…·Eugenia V. Gurevich
The paper shows that restoring arrestin-3 in dopamine-depleted striatum rescues behavioral sensitization by reactivating JNK3 and c-Jun phosphorylation.
DOI 10.1101/2023.10.27.564447