Richard C. Sando

The Adhesion GPCR Flamingo-Like 1 (FMIL-1) Directs Synapse Formation in a Nociceptive Circuit

The paper identifies FMIL-1 as a gene that directs synapse formation in a C. elegans nociceptive circuit by promoting connectivity between PVD neurons and PVC/AVA interneurons.

Stable excitatory-inhibitory synapse balance despite dynamic turnover

The paper develops methods to track excitatory and inhibitory synapses and finds their densities remain steady during maturation despite dynamic turnover.

The atypical adhesion GPCR ADGRA1 controls hippocampal inhibitory circuit function

This study identifies ADGRA1 as essential for hippocampal inhibitory synaptic function in PV and SST interneurons, showing its role in synaptic inputs and learning/memory.

Arrestin-3 scaffolds multiple MAP3Ks driving stress-induced JNK3 activation and cell death.

This study identifies arrestin-3 as a scaffold for multiple MAP3Ks, with ZAK being the main mediator of JNK3 activation and chemotherapy-induced cell death in HEK293 cells.

The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation

The paper identifies ADGRL2's role in epidermal differentiation through Gα13 activation and structural interactions, using CRISPR, Perturb-seq, and cryo-EM.

Cytoplasmic tail composition modulates the G protein and arrestin-3 signaling bias of the adhesion GPCR LPHN2

This study shows that the C-terminal tail of LPHN2 modulates G protein and arrestin-3 signaling bias through alternative splicing and GRK interactions.

The Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses

This study shows that Lphn1 is present in both excitatory and inhibitory synapses but is not essential for excitatory transmission, instead contributing to inhibitory synapse formation and function.

Dissociating encoding of memory and salience by manipulating long-term synaptic potentiation

This study uses a novel approach to block long-term potentiation and finds that it selectively enhances salience coding in hippocampal neurons without affecting spatial memory.

A toolbox of nanobodies developed and validated for diverse neuroscience research applications

The paper develops and validates a set of nanobodies for targeting proteins in brain neurons, providing a toolbox for visualization and modulation of subcellular sites.