Céline Eidenschenk

This paper develops scalable human neuron models of Alzheimer's disease to reveal mechanisms linking Tau fibrillization to synaptic dysfunction and identifies therapeutic targets.

OAK enables ultra-high throughput single-cell multiomic profiling with high sensitivity and reduced labor, demonstrating its utility in detecting rare resistant cell populations.

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

The paper develops a CRISPRi-based screening platform to identify genes affecting neuronal excitability in human iPSC-derived neurons, revealing new links to neurodegenerative and neurodevelopmental disorders.