The paper develops an AI pipeline to automatically segment IMPDH2 rod-ring structures in mouse ESCs, achieving high accuracy and agreement with expert annotations.

BMC Biology · May 11, 2025Peer-reviewedBioinformatics

Identification of a novel therapeutic agent for Inflammatory Bowel Disease guided by systems medicine

Katie Lloyd, Stamatia Papoutsopoulou, Emily Smith, Philip Stegmaier, François Bergey, Lorna Morris, Madeleine Kittner, Hazel England, David G. Spiller, Michael White, Carrie A. Duckworth, Barry James Campbell, Vladimir Poroikov, Vítor A. P. Martins dos Santos, Alexander E Kel, , Michael David Burkitt

This study identifies clarithromycin as a potential therapeutic for inflammatory bowel disease through in-silico drug repositioning and experimental validation of its effects on NF-κB signaling.

Disease Models & Mechanisms · Sep 21, 2020Peer-reviewedSystems Biology

Multiplexing information flow through dynamic signalling systems

Giorgos Minas, Dan J. Woodcock, Louise Ashall, Claire V. Harper, Michael White, David A. J. Rand

This paper defines and mathematically characterizes multiplexing in signaling systems, provides experimental evidence for NF-κB's potential to multiplex information, and introduces new methods for analyzing dynamic models.

PLoS Computational Biology · Aug 3, 2020Peer-reviewedSystems Biology

ER stress-linked autophagy stabilizes apoptosis effector PERP and triggers its co-localization with SERCA2b at ER-plasma membrane junctions

Samantha J. Brace-McDonnell, David G. Spiller, Michael White, Ian A. Prior, Luminita Paraoan

This study identifies a novel interaction between PERP and SERCA2b at ER-PM junctions under ER stress, linking autophagy to apoptosis.

Cell Death Discovery · Sep 2, 2019Peer-reviewedMolecular Biology