Guillaume Velasco

This study shows that Chlamydia trachomatis infection causes global histone hypermethylation by inhibiting demethylation, leading to altered transcription and affecting infection outcomes.

This study shows that SETDB1 regulates LADs and nuclear mechanics by modulating H3K9me3, affecting cancer cell migration without major transcriptional changes.

This study shows that SETDB1 automethylation on H3K9-like motifs is essential for its function in ESCs, affecting chromodomain interactions and H3K9me3 establishment.

This study identifies ZBTB24 as a transcription factor that regulates DNA methylation and expression of centromeric satellite repeats in human and mouse cells.

This study uses tunable DNMT1 degradation to investigate DNA methylation dynamics and genome organization, revealing cooperative roles of DNMT1 and DNMT3B and their impact on heterochromatin and cell fitness.