Author

Xukai Jiang

Shandong UniversityORCID 0000-0002-3624-8732Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Approach:diffusion model· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Min Xiao· 3 shared Limei Xu· 2 shared Chunyi YangiD· 1 shared Fanfan ZhouiD· 1 shared Hengde Li· 1 shared Jian LiiD· 1 shared Jingyi ZhuiD· 1 shared Kade D. Roberts· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

Min Xiao

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Lateral opening site of human oligopeptide transporter 2 plays a key role in the interaction with polymyxins

Xukai Jiang, Yining Luo, Mohammad A. K. Azad, Limei Xu, Min Xiao, Tony Velkov, Kade D. Roberts, Visanu Thamlikitkul, Qi Tony Zhou, Fanfan Zhou, Jian Li

This study identifies key residues in hPepT2 involved in polymyxin interaction, showing that modifying these residues reduces nephrotoxicity while maintaining antibacterial activity.

eLife · Oct 29, 2026Peer-reviewedBiochemistry

Collaborative multi-agent intelligence uncovers subtype-selective allosteric sites at GPCR-lipid interaction interface

Jingyi Zhu, Hengde Li, Min Xiao, Lushan Wang, Xukai Jiang

The paper identifies subtype-selective allosteric sites at GPCR-lipid interfaces using a multi-agent workflow and screens compounds to find ligand candidates.

bioRxiv · Aug 7, 2026 · PreprintBiochemistry

Beyond Generic Signal Peptides: ApexSP Enables Cargo-Specific Secretion Design

Chunyi Yang, Ruiyang Hou, Zhenyu Ma, QiuYan Kang, Shuojing Zuo, Limei Xu, Min Xiao, Xiuyun Wu, Xukai Jiang

ApexSP designs cargo-specific signal peptides for efficient secretion by integrating evolutionary information, compatibility modeling, and experimental validation across multiple expression systems.

bioRxiv · Jul 30, 2026 · PreprintSynthetic Biology