Lateral opening site of human oligopeptide transporter 2 plays a key role in the interaction with polymyxins
Xukai Jiang, Yining Luo, Mohammad A. K. Azad, Limei Xu, Min Xiao, Tony Velkov, Kade D. Roberts, Visanu Thamlikitkul, Qi Tony Zhou, Fanfan Zhou, Jian Li
This study identifies key residues in hPepT2 involved in polymyxin interaction, showing that modifying these residues reduces nephrotoxicity while maintaining antibacterial activity.
eLife · Oct 29, 2026Peer-reviewedBiochemistry