Amin Polzin

Impaired mitochondrial ketone body oxidation in insulin resistant states

This study shows reduced mitochondrial ketone body oxidation in insulin resistant states across multiple organs in humans and mice.

Distinct effects of acute and chronic blood loss anemia on vascular function after acute myocardial infarction

This study compares the effects of acute and chronic blood loss anemia on vascular function after myocardial infarction in mice, finding both types impair endothelial function with chronic anemia additionally reducing vascular smooth muscle contractility.

Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure

This study shows that mutant Huntingtin causes neurodevelopmental issues in human brain organoids by disrupting CHCHD2, leading to mitochondrial and metabolic problems.

Platelets induce cell apoptosis of cardiac cells via FasL after acute myocardial infarction

This study shows that platelets induce cardiac cell apoptosis via FasL after acute myocardial infarction, contributing to cardiac damage and dysfunction.