Author

Darcy T. Ahern

University of ConnecticutORCID 0000-0002-3630-4538Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:ChIP-seq· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Prakhar BansaliD· 4 shared Stefan F. PinteriD· 4 shared Yuvabharath KondaveetiiD· 4 shared Erin C. BandaiD· 3 shared Heather R. Glatt-DeeleyiD· 3 shared Isaac V. FaustinoiD· 2 shared Rachael E. MasseyiD· 2 shared Catherine W. QiuiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersDevelopmental Biology

Prakhar BansalORCID

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4 papers

Recent·Most cited

Isogenic hiPSC models of Turner syndrome development reveal shared roles of inactive X and Y in the human cranial neural crest network

Darcy T. Ahern, Prakhar Bansal, Isaac V. Faustino, Owen M. Chambers, Erin C. Banda, Heather R. Glatt-Deeley, Rachael E. Massey, Yuvabharath Kondaveeti, Stefan F. Pinter

The paper uses isogenic hiPSC-derived neural crest cells to identify gene expression changes in Turner syndrome, revealing haploinsufficient drivers in cranial neural crest development.

The American Journal of Human Genetics · Feb 7, 2025Peer-reviewedDevelopmental Biology

A dynamic in vitro model of Down Syndrome neurogenesis with Trisomy 21 gene dosage correction

Prakhar Bansal, Erin C. Banda, Heather R. Glatt-Deeley, Christopher E. Stoddard, Jeremy W. Linsley, Neha Arora, Cécile Deleschaux, Darcy T. Ahern, Yuvabharath Kondaveeti, Rachael E. Massey, Michaël Nicouleau, Shijie Wang, Miguel Sabariego-Navarro, Mara Dierssen, Steven M. Finkbeiner, Stefan F. Pinter

This study uses a dynamic in vitro model to correct Trisomy 21 gene dosage in DS neurogenesis and shows XIST can suppress chr21 genes even after terminal differentiation.

Science Advances · Jun 7, 2024Peer-reviewedDevelopmental Biology

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta

Darcy T. Ahern, Prakhar Bansal, Maria K. Armillei, Isaac V. Faustino, Yuvabharath Kondaveeti, Heather R. Glatt-Deeley, Erin C. Banda, Stefan F. Pinter

The paper uses isogenic hiPSCs to study monosomy X effects on trophoblast gene expression and finds altered placental gene levels and preserved co-expression modules in placental tissues.

Proceedings of the National Academy of Sciences · Sep 26, 2022Peer-reviewedDevelopmental Biology

Contiguous Erosion of the Inactive X in Human Pluripotency Concludes With Global DNA Hypomethylation

Prakhar Bansal, Darcy T. Ahern, Yuvabharath Kondaveeti, Catherine W. Qiu, Stefan F. Pinter

The paper analyzes DNA methylation, chromatin accessibility, and gene expression in human pluripotent stem cells to trace X chromosome erosion and its impact on epigenetic features and pluripotency.

Cell Reports · Jun 1, 2021Peer-reviewedGenomics