Miguel Sabariego-Navarro

This study uses a dynamic in vitro model to correct Trisomy 21 gene dosage in DS neurogenesis and shows XIST can suppress chr21 genes even after terminal differentiation.

The paper uses single nucleus RNA-seq to analyze the hippocampus of a Down syndrome mouse model, identifying transcriptomic changes and a novel long-non-coding gene involved in cognitive phenotypes.

This study investigates engram formation in a Down syndrome mouse model and finds reduced engram cell numbers and impaired neuronal function in the dentate gyrus.