Mara Dierssen

The paper develops a computational model of the mouse motor cortex to study how neuromorphological changes in Down syndrome affect gamma oscillations, finding reduced gamma activity in DS models.

This study uses a dynamic in vitro model to correct Trisomy 21 gene dosage in DS neurogenesis and shows XIST can suppress chr21 genes even after terminal differentiation.

The paper uses single nucleus RNA-seq to analyze the hippocampus of a Down syndrome mouse model, identifying transcriptomic changes and a novel long-non-coding gene involved in cognitive phenotypes.

This study investigates how Dyrk1A overexpression in mice affects neuronal network activity, finding that structural deficits, not over-inhibition, primarily impair network function.

This study investigates engram formation in a Down syndrome mouse model and finds reduced engram cell numbers and impaired neuronal function in the dentate gyrus.

The paper introduces a new analytical pipeline for metatranscriptomic analysis and applies it to study gut microbiome changes in a Down syndrome mouse model under high-fat diet.

This study shows environmental enrichment alters chromatin structure, transcription factor binding, and 3D genome organization in mice, affecting cognitive function and gene regulation.

The paper develops a deep learning algorithm to predict neurite structure and length in fluorescence imaging, achieving near-human accuracy and efficiency for large datasets.

The paper characterizes the microbiome of Down syndrome mouse models under standard and high-fat diets, finding increased microbial diversity and specific bacterial enrichment in trisomic mice.

This study shows EGCG treatment improves facial dysmorphology in DS mouse models and humans but warns against non-prescribed use due to variable outcomes.