Author

Zhi Yao

LifeArcORCID 0000-0002-9490-3870Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Andrey Y. AbramoviD· 2 shared Daniela MelandriiD· 2 shared Dilan S. AthaudaiD· 2 shared Gurvir S. VirdiiD· 2 shared James R. EvansiD· 2 shared Minee L. ChoiiD· 2 shared Rickie PataniiD· 2 shared Sergiy SylantyeviD· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Andrey Y. AbramovORCID

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Author profile →

4 papers

Recent·Most cited

Glutamic Acid at position 168 is a constitutive activator of Tank Binding Kinase 1 catalytic function

Noopur Bhore, Anubhuti Sarkar, Zhi Yao, Susanne Herbst, Patrick Alfryn Lewis

The paper investigates the role of glutamic acid at position 168 in TBK1 kinase activity, finding it acts as a constitutive activator.

NeuroMolecular Medicine · Nov 5, 2025Peer-reviewedBiochemistry

Harnessing Transcriptomic Signals for Amyotrophic Lateral Sclerosis to Identify Novel Drugs and Enhance Risk Prediction

Oliver Pain, Ashley Jones, Ahmad Al Khleifat, Devika Agarwal, Dzmitry Hramyka, Hajer Karoui, Jędrzej Kubica, David J. Llewellyn, Janice M. Ranson, Zhi Yao, Alfredo Iacoangeli, Ammar Al‐Chalabi

This study uses GWAS and functional genomics to identify ALS risk genes, repurpose drugs, and improve risk prediction using polytranscriptomic scores.

Heliyon · Jul 29, 2024Peer-reviewedGenetic & Genomic Medicine

Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons

Gurvir S. Virdi, Minee L. Choi, James R. Evans, Zhi Yao, Dilan S. Athauda, Stephanie Strohbuecker, Raja Sekhar Nirujogi, Anna I. Wernick, Noelia Pelegrina‐Hidalgo, Craig Leighton, Rebecca S. Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, , Sonia Gandhi

This study uses hiPSCs with SNCA mutations to identify early molecular events in synucleinopathy, showing protein aggregation precedes functional impairments in midbrain dopaminergic neurons.

npj Parkinson s Disease · Nov 24, 2022Peer-reviewedNeuroscience

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson's disease.

Gurvir S. Virdi, Minee L. Choi, Zhi Yao, James R Evans, Dilan S. Athauda, Daniela Melandri, Sergiy Sylantyev, Andrey Y. Abramov, Rickie Patani, Sonia Gandhi

This paper develops a method to generate highly enriched midbrain dopaminergic neurons from hiPSCs, which model Parkinson's disease features like synucleinopathy and mitochondrial dysfunction.

bioRxiv · Sep 8, 2020 · PreprintNeuroscience